Acetyl chloride → 1-(2-aminoethyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-amine dihydrochloride

HRID 1984400Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1984400
C([Cl:4])(=O)C.[NH2:5][C:6]1[C:15]2=[N:16][N:17]([CH2:29][CH2:30][CH3:31])[C:18]([CH2:19][CH2:20][NH:21]C(=O)OC(C)(C)C)=[C:14]2[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N:7]=1>C(O)C>[ClH:4].[ClH:4].[NH2:21][CH2:20][CH2:19][C:18]1[N:17]([CH2:29][CH2:30][CH3:31])[N:16]=[C:15]2[C:14]=1[C:13]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N:7]=[C:6]2[NH2:5]

Komponenten

4

Edukt 2

HCID 6367Acetyl chlorideHCID 66958848tert-butyl 2-(4-amino-2-propyl-2H-pyrazolo[3,4-c]quinolin-1-yl)ethylcarbamate

Produkt 1

HCID 669590441-(2-aminoethyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-amine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Acetyl chloride (7.1 mL, 100 mmol) was added to ethanol (100 mL) at 0° C. The resulting solution was added to the tert-butyl 2-(4-amino-2-propyl-2H-pyrazolo[3,4-c]quinolin-1-yl)ethylcarbamate from Part G. The solution was heated at reflux for 9.5 hours. Upon cooling to ambient temperature, a precipitate formed that was isolated after two days by filtration, washed with a small amount of cold ethanol, and dried to yield 5.78 g of 1-(2-aminoethyl)-2-propyl-2H-pyrazolo[3,4-c]quinolin-4-amine dihydrochloride as a white solid.

Aufarbeitung

  1. temperatureThe solution was heated
  2. temperatureat reflux for 9.5 hours
  3. customa precipitate formed
  4. customthat was isolated after two days by filtration
  5. washwashed with a small amount of cold ethanol
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-1c130c3cc1a04bddad1d04516f794d55
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07544697B2

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