HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1984627Erstellt: 27. Oktober 2026
1-Acetylpiperazine → 4-[2-(4-Acetylpiperazin-1-yl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde
https://huagongshe.com/reaction/1984627
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 1-Acetylpiperazine | HCID 83795 | — |
| Edukt | 4-[2-(Ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde | HCID 57713940 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | 4-[2-(4-Acetylpiperazin-1-yl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde | HCID 57713944 | — |
Reaktionsschritte
To a solution of 4-[2-(ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde (3-1; 63 mg, 0.16 mmole) in dioxane (1 mL) was added 1-acetylpiperazine and heated to 150° C. in a microwave reactor for 30 min. The mixture was concentrated under reduced pressure and the residue was purified by silica gel chromatography (100% Hex. to 100% EtOAc) to give the title compound. LRMS m/z (M+H) Calcd: 438.5, found 438.2.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US07544677B2 |
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| Quelldatensatz | uspto-grants-2009_06 |
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| ORD ID | ord-019e8fb0e76c45ddba9887176813719c |
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| Quellennotiz | uspto-grants-2009_06 |
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