n,n-Dimethylpiperazine-1-carboxamide → 4-[7-(4-formylphenyl)-6-phenylpyrido[2,3-d]pyrimidin-2-yl]-N,N-dimethylpiperazine-1-carboxamide

HRID 1984637

Reaktionsgleichung

C(S([C:5]1[N:6]=[CH:7][C:8]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:12]([C:21]3[CH:28]=[CH:27][C:24]([CH:25]=[O:26])=[CH:23][CH:22]=3)=[N:11][C:9]=2[N:10]=1)=O)C.[CH3:29][N:30]([CH3:39])[C:31]([N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1)=[O:32]>O1CCOCC1>[CH:25]([C:24]1[CH:27]=[CH:28][C:21]([C:12]2[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:14][C:8]3[CH:7]=[N:6][C:5]([N:36]4[CH2:35][CH2:34][N:33]([C:31]([N:30]([CH3:39])[CH3:29])=[O:32])[CH2:38][CH2:37]4)=[N:10][C:9]=3[N:11]=2)=[CH:22][CH:23]=1)=[O:26]

Komponenten

Reaktionsbedingungen

Temperatur: 150 °C

Versuchsvorschrift

To a solution of 4-[2-(ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde (6-4; 100 mg, 0.258 mmole) in dioxane (1 mL) was added N,N-dimethylpiperazine-1-carboxamide (48 mg, 0.309 mmole) and heated to 150° C. in a microwave reactor for 30 min. The mixture was concentrated under reduced pressure and the residue was purified by silica gel chromatography (100% Hex. to 100% EtOAc) to give the title compound. LRMS m/z (M+H) Calcd: 467.2, found 467.1.

Aufarbeitung

concentrationThe mixture was concentrated under reduced pressure
customthe residue was purified by silica gel chromatography (100% Hex. to 100% EtOAc)

Quellen und Nachweise

ORD-Eintrag: ord-af3ea743f8a548be9a28127dfcf48c7f
Quelldatensatz: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07544677B2

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