Borane → HCID 68854758, Verbindung

HRID 1984691Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1984691
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[N:11][C:10]([C:14](O)=[O:15])=[N:9]2)=[CH:4][CH:3]=1.B>C1COCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([CH3:13])=[N:11][C:10]([CH2:14][OH:15])=[N:9]2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 6331BoraneHCID 35813371-(4-fluorophenyl)-5-methyl-1H-1,2,4-triazole-3-carboxylic acid

Produkt 1

HCID 68854758HCID 68854758, VerbindungAusbeute 46 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a suspension of 1-(4-fluoro-phenyl)-5-methyl-1H-[1,2,4]triazole-3-carboxylic acid (may be prepared in analogy to DE3525205, 1986, 10.7 g, 48.4 mmol) in THF (50 mL) was added borane (1 M in THF, 121 mL, 121 mmol) and the resulting suspension was heated to reflux for 1 h. After concentration and extraction with aqueous sodium hydrogencarbonate and ethyl acetate the combined organic layers were washed with brine and dried over sodium sulfate. Concentration and purification by chromatography (SiO2, hexane:ethyl acetate=100:0 to 33:67) afforded the title compound (4.60 g, 46%) as a white solid. MS: m/e=208.4 [M+H]+.

Aufarbeitung

  1. temperaturethe resulting suspension was heated
  2. temperatureto reflux for 1 h
  3. concentrationAfter concentration and extraction with aqueous sodium hydrogencarbonate and ethyl acetate the combined organic layers
  4. washwere washed with brine
  5. dry with materialdried over sodium sulfate
  6. concentrationConcentration and purification by chromatography (SiO2, hexane:ethyl acetate=100:0 to 33:67)

Quellen und Nachweise

ORD-Eintrag
ord-5f14978bc9c2480ca73d98390b800a8d
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07544704B2

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