Theophylline → Diethyl [4-(1,3-dimethylxanthin-7-yl)butyl]phosphonate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

10.9 g (0.05 mol) of 1,3-dimethylxanthine were suspended in 150 ml of DMF, treated with 13.7 g (0.06 mol) of diethyl 4-chlorobutanephosphonate and 7.0 g (0.05 mol) of activated potassium carbonate and heated at 70° C. for approximately 4 hours. The solid was then filtered off, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.

Herkunft & Nachweise