HCID 57719408, Verbindung → HCID 57719830, Verbindung

HRID 1985392Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1985392
[CH3:1][O:2][C:3](=[O:25])[C@@H:4]([O:21][CH:22]([CH3:24])[CH3:23])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][NH:13]C(OC(C)(C)C)=O)[CH:7]=1>O1CCOCC1.Cl>[CH3:1][O:2][C:3](=[O:25])[C@@H:4]([O:21][CH:22]([CH3:23])[CH3:24])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][NH2:13])[CH:7]=1

Komponenten

3

Edukt 1

HCID 57719408HCID 57719408, Verbindung

Produkt 1

HCID 57719830HCID 57719830, VerbindungAusbeute 88,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 204431481,4-Dioxane hydrochlorideLösungsmittel

Versuchsvorschrift

1.034 g of 3-[3-(t-Butoxycarbonylaminomethyl)phenyl]-2(S)-isopropoxypropionic acid methyl ester was dissolved in 20 ml of hydrogen chloride 1,4-dioxane, and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated, the residue was dissolved in ethyl acetate, and washed with saturated aqueous sodium hydrogen carbonate. The organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 653 mg of the title compound as a colorless oil.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washwashed with saturated aqueous sodium hydrogen carbonate
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-c6fbee78640042efb8b93a3afec12143
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07544835B2

Notizen zur Reaktion

Wird geladen…