HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-amino-N-cyclopropyl-2,4-difluorobenzamide → 6-{5-[(5-Cyclopropylcarbamoyl-2,4-difluoro-phenylamino)-methyl]-thiazol-2-ylamino}-nicotinic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-amino-N-cyclopropyl-2,4-difluorobenzamide | HCID 21966507 | — |
| Edukt | 6-(5-Formyl-thiazol-2-ylamino)-nicotinic acid | HCID 22019054 | — |
| Produkt | 6-{5-[(5-Cyclopropylcarbamoyl-2,4-difluoro-phenylamino)-methyl]-thiazol-2-ylamino}-nicotinic acid | HCID 23544562 | 95% |
Reaktionsschritte
6-(5-Formyl-thiazol-2-ylamino)-nicotinic acid (see Example 19) was treated with 5-amino-2,4-difluoro-N-cyclopropylbenzamide in manner similar to the preparation of Example 6 to afford the title compound in 95% yield. LC/MS; (M+H)+=446
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07547711B2 |
| Quelldatensatz | uspto-grants-2009_06 |
| ORD ID | ord-be38a8ea2f544ad99a59a26cc4085c5b |
| Quellennotiz | uspto-grants-2009_06 |