2-Azido-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1H-benzimidazole → 2-Amino-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1H-benzimidazole

HRID 1985816Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1985816
[N:1]([C:4]1[N:8]([C@@H:9]2[O:21][C@H:20]([CH2:22][O:23][C:24](=[O:26])[CH3:25])[C@@H:15]([O:16][C:17](=[O:19])[CH3:18])[C@H:10]2[O:11][C:12](=[O:14])[CH3:13])[C:7]2[CH:27]=[CH:28][CH:29]=[CH:30][C:6]=2[N:5]=1)=[N+]=[N-]>CO.[C].[Pd]>[NH2:1][C:4]1[N:8]([C@@H:9]2[O:21][C@H:20]([CH2:22][O:23][C:24](=[O:26])[CH3:25])[C@@H:15]([O:16][C:17](=[O:19])[CH3:18])[C@H:10]2[O:11][C:12](=[O:14])[CH3:13])[C:7]2[CH:27]=[CH:28][CH:29]=[CH:30][C:6]=2[N:5]=1

Komponenten

4

Edukt 1

HCID 866182782-Azido-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1H-benzimidazole

Produkt 1

HCID 688410382-Amino-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1H-benzimidazoleAusbeute 103,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

2-Azido-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-benzimidazole (100 mg) was dissolved in methanol (2 mL). To the solution was added a catalytic amount of 10% palladium-carbon powder, and the mixture was stirred at room temperature under a hydrogen atmosphere for 1 hour. The insoluble material was removed by filtration, and the solvent of filtrate was removed under reduced pressure to give the title compound (97 mg).

Aufarbeitung

  1. customThe insoluble material was removed by filtration
  2. customthe solvent of filtrate was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-73cb82c0a8ce43b08e8ff1e807522535
Quelldatensatz
uspto-grants-2009_06
Patentnummer
US07547680B2

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