1,2-Dibromoethane → 7-(4-chlorophenyl)-2-(3-methoxy-4-(2-(tetrahydrofuran-2-yl)ethoxy)phenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:13]([NH:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH:25]4[CH2:29][CH2:28][CH2:27][O:26]4)=[C:18]([O:30][CH3:31])[CH:17]=3)=[O:14])[NH:11][CH:12]=2)=[CH:4][CH:3]=1.Br[CH2:33][CH2:34]Br>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]3[C:13](=[O:14])[N:15]([C:16]4[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][CH:25]5[CH2:29][CH2:28][CH2:27][O:26]5)=[C:18]([O:30][CH3:31])[CH:17]=4)[CH2:34][CH2:33][N:11]3[CH:12]=2)=[CH:4][CH:3]=1Komponenten
3
Versuchsvorschrift
Following the procedure described in Example 1 step D, the product of step B (120 mg) was alkylated with 1,2-dibromoethane to yield 20 mg of the title compound. MS (ESI) 467 (M+H)+.
Quellen und Nachweise
- ORD-Eintrag
- ord-45a7168a2a0745bea2d9480ee53f837e