Benzenemethanol, 2-ethoxy- → 4-[(2-Ethoxyphenyl)methoxy]-3-nitropyridine

Reaktionsgleichung

Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[CH2:11]([O:13][C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[CH2:16][OH:17])[CH3:12]>>[CH2:11]([O:13][C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[CH2:16][O:17][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9])[CH3:12]

Komponenten

Edukt 2

HCID 51381Benzenemethanol, 2-ethoxy-

HCID 27357814-Chloro-3-nitropyridine

Produkt 1

HCID 686994514-[(2-Ethoxyphenyl)methoxy]-3-nitropyridineAusbeute 65,9 %

Versuchsvorschrift

In accordance with the same procedures as in Preparation 2, except for using 4-chloro-3-nitropyridine prepared in Step 1 of Preparation 1 and 2-ethoxybenzyl alcohol, the titled compound was obtained as a yellow solid. (Yield: 65.9%)

Aufarbeitung

customIn accordance with the same procedures as in Preparation 2

Quellen und Nachweise

ORD-Eintrag: ord-f299e3a440e24a7d8759b36c84e7f08c
Quelldatensatz: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07642269B2

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