Ethyl 3-(4-bromo-2-hydroxyphenyl)-3-oxopropanoate → 7-Bromo-4-hydroxycoumarin

HRID 1988889Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1988889
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:15])[CH2:9][C:10]([O:12]CC)=O)=[C:4]([OH:16])[CH:3]=1>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]2[C:5]([C:8]([OH:15])=[CH:9][C:10](=[O:12])[O:16]2)=[CH:6][CH:7]=1

Komponenten

3

Edukt 1

HCID 59127384Ethyl 3-(4-bromo-2-hydroxyphenyl)-3-oxopropanoate2×

Produkt 1

HCID 546962297-Bromo-4-hydroxycoumarinAusbeute 78,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of ethyl 3-(4-bromo-2-hydroxyphenyl)-3-oxopropanoate (Intermediate 30) (2.0 g) in dry toluene (20 ml) was stirred at reflux under nitrogen for 24 h. On cooling the resulting precipitate was collected by filtration, washed with ether and dried to give the title compound as a white solid (1.32 g).

Aufarbeitung

  1. temperatureat reflux under nitrogen for 24 h
  2. temperatureOn cooling the resulting precipitate
  3. filtrationwas collected by filtration
  4. washwashed with ether
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ca540a040e4345979095e68bbca15e30
Quelldatensatz
uspto-grants-2010_01
Patentnummer
US07642276B2

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