2-Iodo-4-methyl-6-(4-trifluoromethyl-phenyl)pyridine → HCID 86615445, Verbindung
Reaktionsgleichung
I[C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1.[Cl:19][C:20]1(B(O)O)[CH:25]=[CH:24][CH:23]=[CH:22][NH:21]1>>[Cl:19][C:20]1[CH:25]=[C:24]([C:2]2[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=3)[N:3]=2)[CH:23]=[CH:22][N:21]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from 2-iodo-4-methyl-6-(4-trifluoromethyl-phenyl)pyridine (example A.58) (5.45 g, 15 mmol) and commercially available 2-chloropyridine boronic acid (2.48 g, 15.75 mmol) according to the general procedure IVb. Obtained as an off-white solid (3.82 g, 73%). MS (ISP) 349.2 [(M+H)+] and 351 [(M+2+H)+].
Quellen und Nachweise
- ORD-Eintrag
- ord-8877c8a14c9e4625a42597eaabd20aa3
- Quelldatensatz
- uspto-grants-2010_01