6-Aminonicotinic acid → HCID 60209355, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]=[C:10]([C:18]([NH:20][OH:21])=[NH:19])[N:9]=2)=[CH:4][CH:3]=1.[NH2:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](O)=O)=[CH:25][N:24]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:15])([F:16])[F:17])[N:11]=[C:10]([C:18]3[N:19]=[C:27]([C:26]4[CH:30]=[CH:31][C:23]([NH2:22])=[N:24][CH:25]=4)[O:21][N:20]=3)[N:9]=2)=[CH:4][CH:3]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from 4-(4-chloro-phenyl)-N-hydroxy-6-trifluoromethyl-pyrimidine-2-carboxamidine (example C.1) (0.16 g, 0.5 mmol) and commercially available 6-amino-nicotinic acid (0.07 g, 0.5 mmol according to the general procedure VI. Obtained as an off-white solid (0.059 g, 28%). MS (ISP) 418.9 [(M+H)+]; mp 191° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-ea77101b82af4cde87c4b3f1b7fbf173
- Quelldatensatz
- uspto-grants-2010_01
- Patentnummer