5-Sulfamoylthiophene-2-carboxylic acid → HCID 57468854, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]=[C:10]([C:18]([NH:20][OH:21])=[NH:19])[N:9]=2)=[CH:4][CH:3]=1.[S:22]([C:26]1[S:27][C:28]([C:31](O)=O)=[CH:29][CH:30]=1)(=[O:25])(=[O:24])[NH2:23]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:15])([F:16])[F:17])[N:11]=[C:10]([C:18]3[N:19]=[C:31]([C:28]4[S:27][C:26]([S:22]([NH2:23])(=[O:25])=[O:24])=[CH:30][CH:29]=4)[O:21][N:20]=3)[N:9]=2)=[CH:4][CH:3]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from 4-(4-chloro-phenyl)-N-hydroxy-6-trifluoromethyl-pyrimidine-2-carboxamidine (example C.1) (0.16 g, 0.5 mmol) and commercially available 2-sulfamoyl-thiophene-5-carboxylic acid [CAS-No. 7353-87-9] (104 mg, 0.5 mmol) according to the general procedure VI. Obtained as a light yellow solid (0.085 g, 35%). MS (ISN) 486.1 [(M−H)−]; mp 236.5° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-9edc9d6452b2454eb6d23ebe9b9b1da4
- Quelldatensatz
- uspto-grants-2010_01