Thionyl Chloride → 3,4-Difluoro-benzoic acid 4-(2-chlorocarbonyl-vinyl)-phenyl ester

HRID 1991917Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1991917
[C:1]([CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13](=[O:22])[C:14]2[CH:19]=[CH:18][C:17]([F:20])=[C:16]([F:21])[CH:15]=2)=[CH:8][CH:7]=1)(O)=[O:2].S(Cl)([Cl:25])=O>C(Cl)Cl>[Cl:25][C:1]([CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13](=[O:22])[C:14]2[CH:19]=[CH:18][C:17]([F:20])=[C:16]([F:21])[CH:15]=2)=[CH:8][CH:7]=1)=[O:2]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 685379543,4-Difluoro-benzoic acid 4-(2-carboxy-vinyl)-phenyl ester

Produkt 1

HCID 723620523,4-Difluoro-benzoic acid 4-(2-chlorocarbonyl-vinyl)-phenyl esterAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
35 °C

Versuchsvorschrift

About 10 g (about 21.68 mmol) of 3,4-difluoro-benzoic acid 4-(2-carboxy-vinyl)-phenyl ester was dissolved in about 200 ml of methylene chloride, and about 2.84 g (23.848 mmol) of thionyl chloride (SOCl2) was added thereto. Thereafter, the reaction mixture was stirred at about 35° C. for about 6 hours, followed by removing the solvent. Subsequently, a vacuum drying process was conducted, thus obtaining the desired compound (Yield about 90%).

Aufarbeitung

  1. customby removing the solvent
  2. customSubsequently, a vacuum drying process

Quellen und Nachweise

ORD-Eintrag
ord-72af5323641546aea381b79ab4b5cbc8
Quelldatensatz
uspto-grants-2010_01
Patentnummer
US07646014B2

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