Triethylamine → N-(3-Bromo-propyl)-4-cyano-benzenesulfonamide

HRID 1992357Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1992357
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2].Br.[Br:14][CH2:15][CH2:16][CH2:17][NH2:18].C(N(CC)CC)C>ClCCl>[Br:14][CH2:15][CH2:16][CH2:17][NH:18][S:9]([C:6]1[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=1)(=[O:11])=[O:10]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 394974-Cyanobenzenesulfonyl chlorideHCID 787013-Bromopropylamine hydrobromide

Produkt 1

HCID 43133733N-(3-Bromo-propyl)-4-cyano-benzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4-Cyanobenzenesulfonyl chloride (5 g, 0.0248 mol) was added dropwise to a solution of 3-bromopropylamine hydrobromide (6.61 g, 0.0302 mol) and triethylamine (6.26 g, 0.062 mol) in dry dichloromethane (50 ml) at 0° C. and stirred at room temperature overnight under nitrogen atmosphere. The reaction was quenched with water and extracted with dichloromethane. The organic layer was washed with water, brine and dried over sodium sulfate.

Aufarbeitung

  1. customThe reaction was quenched with water
  2. extractionextracted with dichloromethane
  3. washThe organic layer was washed with water, brine
  4. dry with materialdried over sodium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-3af1aa919d5c4a828056269fa8c41bc5
Quelldatensatz
uspto-grants-2010_01
Patentnummer
US07648985B2

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