HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Chloropyridine-4-boronic acid → [1-(2-Chloro-pyridin-4-yl)-5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-cyclopropanesulfonyl-piperazin-1-yl)-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Chloropyridine-4-boronic acid | HCID 5151595 | — |
| Edukt | (4-Cyclopropanesulfonyl-piperazin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone | HCID 68535679 | — |
| Produkt | [1-(2-Chloro-pyridin-4-yl)-5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-cyclopropanesulfonyl-piperazin-1-yl)-methanone | HCID 86621935 | 61% |
Reaktionsschritte
The title compound was synthesized in analogy to example 5, from (4-cyclopropanesulfonyl-piperazin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone (example 33) and 2-chloropyridine-4-boronic acid to afford the desired product as light-brown foam (61%). MS (ISP): 599.4 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07648979B2 |
| Quelldatensatz | uspto-grants-2010_01 |
| ORD ID | ord-e1cb0b92043c4f2a8e1b3d8752ead8e2 |
| Quellennotiz | uspto-grants-2010_01 |