n,n-Dimethylpiperazine-1-carboxamide → 4-[2-(4-Dimethylcarbamoyl-piperazine-1-carbonyl)-1-isopropyl-1H-indole-5-carbonyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester

HRID 1992495

Reaktionsgleichung

Reaktionsgleichung von HRID 1992495
[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]([C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[N:22]([CH:26]([CH3:28])[CH3:27])[C:21]([C:29]([OH:31])=O)=[CH:20]3)=[O:16])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:32][N:33]([CH3:42])[C:34]([N:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1)=[O:35]>>[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]([C:17]2[CH:18]=[C:19]3[C:23](=[CH:24][CH:25]=2)[N:22]([CH:26]([CH3:28])[CH3:27])[C:21]([C:29]([N:39]2[CH2:38][CH2:37][N:36]([C:34](=[O:35])[N:33]([CH3:32])[CH3:42])[CH2:41][CH2:40]2)=[O:31])=[CH:20]3)=[O:16])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 712909n,n-Dimethylpiperazine-1-carboxamideHCID 685382125-(4-tert-butoxycarbonyl-[1,4]diazepane-1-carbonyl)-1-isopropyl-1H-indole-2-carboxylic acid

Produkt 1

HCID 685366214-[2-(4-Dimethylcarbamoyl-piperazine-1-carbonyl)-1-isopropyl-1H-indole-5-carbonyl]-[1,4]diazepane-1-carboxylic acid tert-butyl ester

Versuchsvorschrift

The title compound was synthesized in analogy to example 47a), from 5-(4-tert-butoxycarbonyl-[1,4]diazepane-1-carbonyl)-1-isopropyl-1H-indole-2-carboxylic acid and piperazine carboxylic acid dimethylamide. Off-white solid. MS (m/z): 569.4 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-b33edda8d02d4852bd685fb715907a25
Quelldatensatz
uspto-grants-2010_01
Patentnummer
US07648979B2

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