Trifluoroacetic acid → HCID 68426417, Verbindung

HRID 1992800Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1992800
C([O:5][C:6]([C:8]1[N:12]([CH2:13][C:14]2[CH:23]=[CH:22][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][N:15]=2)[N:11]=[C:10]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[C:26]([Cl:31])[CH:25]=2)[CH:9]=1)=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:31][C:26]1[CH:25]=[C:24]([C:10]2[CH:9]=[C:8]([C:6]([OH:7])=[O:5])[N:12]([CH2:13][C:14]3[CH:23]=[CH:22][C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][N:15]=3)[N:11]=2)[CH:29]=[CH:28][C:27]=1[Cl:30]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 68425331HCID 68425331, Verbindung

Produkt 1

HCID 68426417HCID 68426417, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of the intermediate from step E (551 mg, 1.19 mmol) in DCM (10 mL) was added TFA (10 mL). After stirring at room temperature for 4 hours the reaction mixture was concentrated in vacuo and azeotroped with toluene (3×). A white solid obtained. This material was used in the next step without any further purification. LC-MS: 2.38 min; (M+H)=406.0.

Aufarbeitung

  1. concentrationwas concentrated in vacuo
  2. customazeotroped with toluene (3×)
  3. customA white solid obtained
  4. customThis material was used in the next step without any further purification
  5. custom2.38 min

Quellen und Nachweise

ORD-Eintrag
ord-c891501b30074510a12d5f0593f50de2
Quelldatensatz
uspto-grants-2010_01
Patentnummer
US07649009B2

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