Methyl 4-nitro-2-(trifluoromethyl)benzoate → Methyl 4-amino-2-(trifluoromethyl)benzoate

HRID 1994124Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1994124
[N+:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([C:14]([F:17])([F:16])[F:15])[CH:5]=1)([O-])=O.O.O.[Sn](Cl)(Cl)(Cl)Cl>CCOC(C)=O>[NH2:1][C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([C:14]([F:15])([F:16])[F:17])[CH:5]=1

Komponenten

4

Edukt 2

HCID 46311176Methyl 4-nitro-2-(trifluoromethyl)benzoateHCID 85782573Tin tetrachloride dihydrate

Produkt 1

HCID 46311081Methyl 4-amino-2-(trifluoromethyl)benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Methyl 4-nitro-2-(trifluoromethyl)benzoate (5.20 g, 20.9 mmol) was dissolved in EtOAc (100 mL) and tin chloride dihydrate (9.41 g, 41.7 mmol) was added to the reaction mixture. The reaction was heated at reflux for 2 h. The crude reaction mixture was purified by column chromatography (SiO2, EtOAc/hexanes) to give the title compound. LCMS: (FA) ES− 218.4 (M−1).

Aufarbeitung

  1. temperatureThe reaction was heated
  2. temperatureat reflux for 2 h
  3. customThe crude reaction mixture
  4. customwas purified by column chromatography (SiO2, EtOAc/hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-5142fc929ec341fcbdd87482b31c9991
Quelldatensatz
uspto-grants-2010_01
Patentnummer
US07652041B2

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