Triethyl orthoacetate → 3-Methyl-6-phenyl[1,2,4]triazolo[4,3-a]pyrazine

HRID 1995062

Reaktionsgleichung

Reaktionsgleichung von HRID 1995062
[NH:1]([C:3]1[CH:8]=[N:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][N:4]=1)[NH2:2].[C:15](OCC)(OCC)(OCC)[CH3:16]>>[C:9]1([C:6]2[N:7]=[CH:8][C:3]3[N:4]([C:15]([CH3:16])=[N:2][N:1]=3)[CH:5]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Komponenten

3

Edukt 2

HCID 66221Triethyl orthoacetateHCID 131998672-Hydrazinyl-5-phenylpyrazine

Produkt 1

HCID 131998743-Methyl-6-phenyl[1,2,4]triazolo[4,3-a]pyrazine

Versuchsvorschrift

A solution of 0.5 g. (0.0027 mole) of 2-hydrazino-5-phenylpyrazine in 5.0 ml. of triethyl orthoacetate is heated under reflux for 5 hours. The crystalline product precipitates from the hot reaction solution, and at the end of the heating period the mixture is cooled and the product is collected. Recrystallization from ethanol gives 0.36 g. of the product of the example, m.p. 192°-195° C.

Aufarbeitung

  1. temperatureunder reflux for 5 hours
  2. customThe crystalline product precipitates from the hot reaction solution
  3. temperatureat the end of the heating period the mixture is cooled
  4. customthe product is collected
  5. customRecrystallization from ethanol
  6. customgives 0.36 g

Quellen und Nachweise

ORD-Eintrag
ord-d0914a405b454da587388b08131ff14a
Quelldatensatz
uspto-grants-1983_09
Patentnummer
US04402958

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