Nitric Acid → 4-Methyl-7-nitro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

HRID 1995511Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1995511
[CH3:1][N:2]1[C:8](=[O:9])[C:7]2[CH:10]=[CH:11][CH:12]=[CH:13][C:6]=2[NH:5][C:4](=[O:14])[CH2:3]1.[N+:15]([O-])([OH:17])=[O:16]>>[CH3:1][N:2]1[C:8](=[O:9])[C:7]2[CH:10]=[C:11]([N+:15]([O-:17])=[O:16])[CH:12]=[CH:13][C:6]=2[NH:5][C:4](=[O:14])[CH2:3]1

Komponenten

3

Edukt 2

HCID 944Nitric AcidHCID 37255754-methyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2,5-dione

Produkt 1

HCID 6165384-Methyl-7-nitro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Versuchsvorschrift

300 ml of 89 percent nitric acid are treated portionwise at room temperature over a period of 35 minutes with 94.5 g. (496.8 mmol) of 3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione. The mixture is stirred at room temperature for 18 hours and poured into 3.5 l of ice-water. The precipitated material is filtered off under suction, washed with water and dried at 70° in vacuo. There is obtained 3,4-dihydro-4-methyl-7-nitro-2H-1,4-benzodiazepine-2,5(1H)-dione of melting point 252°-253°.

Aufarbeitung

  1. filtrationThe precipitated material is filtered off under suction
  2. washwashed with water
  3. customdried at 70° in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c576730015cf4fd6994e15195c9b18f4
Quelldatensatz
uspto-grants-1983_09
Patentnummer
US04405516

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