Protocatechuic Acid → Methyl 3,4-Dihydroxybenzoate

HRID 19984

Reaktionsgleichung

Reaktionsgleichung von HRID 19984
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([OH:7])=[O:6].Cl.[CH3:13]O>>[CH3:13][O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([OH:11])=[C:2]([OH:1])[CH:3]=1

Komponenten

4

Edukt 3

HCID 72Protocatechuic AcidHCID 313Hydrochloric AcidHCID 887Methanol

Produkt 1

HCID 287064Methyl 3,4-DihydroxybenzoateAusbeute 86,5 %

Versuchsvorschrift

A solution of 3,4-dihydroxy benzoic acid (2.8 g) in methanol (150 ml) was refluxed in presence of concentrated hydrochloric acid (0.5 ml) for 12 hrs. After concentrating under reduced pressure, the residue was dissolved in ethyl acetate (150 ml) and washed with water (50 ml) 10% sodium bicarbonate solution (50 ml), brine solution (50 ml) and dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure provided 2.64 g of 3,4-dihydroxybenzoic acid methyl ester. (Yield 86.5%).

Aufarbeitung

  1. concentrationAfter concentrating under reduced pressure
  2. dissolutionthe residue was dissolved in ethyl acetate (150 ml)
  3. washwashed with water (50 ml) 10% sodium bicarbonate solution (50 ml), brine solution (50 ml)
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customRemoval of the solvent under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-10c90eac3e5d4cd08e4480474dc581bb
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745490B2

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