Nitromethane → 1-(3,5-Difluorophenyl)-2-nitroethanol

Beteiligte Stoffe

Reaktionsschritte

Add nitromethane (200 mL) to a suspension of potassium carbonate (30 g) and 3,5-difluorobenzaldehyde (200 g) in tetrahydrofuran (600 mL) at room temperature. Stir at room temperature overnight, filter, wash with ethyl acetate and concentrate to give the desired compound as a crude oil (330 g) which is used in the next step without further purification.

Herkunft & Nachweise