Hydrochloric Acid → 2,2-Dimethyl-3-(2-(7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yloxy)propan-1-amine trihydrochloride

HRID 2035673Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2035673
[CH3:1][C:2]([CH3:34])([CH2:12][O:13][C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[C:23]=1[N:22]=[C:21]([C:24]1[N:28]3[CH:29]=[CH:30][C:31]([CH3:33])=[CH:32][C:27]3=[N:26][N:25]=1)[CH:20]=[CH:19]2)[CH2:3][NH:4]C(=O)OC(C)(C)C.[ClH:35]>ClCCl>[ClH:35].[ClH:35].[ClH:35].[CH3:1][C:2]([CH3:34])([CH2:12][O:13][C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[C:23]=1[N:22]=[C:21]([C:24]1[N:28]3[CH:29]=[CH:30][C:31]([CH3:33])=[CH:32][C:27]3=[N:26][N:25]=1)[CH:20]=[CH:19]2)[CH2:3][NH2:4]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 67230779Tert-butyl 2,2-dimethyl-3-(2-(7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yloxy)propylcarbamate

Produkt 1

HCID 672331932,2-Dimethyl-3-(2-(7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yloxy)propan-1-amine trihydrochlorideAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of tert-butyl 2,2-dimethyl-3-(2-(7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yloxy)propylcarbamate (35 mg, 0.076 mmol) and hydrochloric acid (4 M in dioxane, 0.57 mL, 2.3 mmol) in dichloromethane (0.5 mL) was stirred overnight. The reaction was concentrated under reduced pressure. The residue was evaporated from twice from toluene, once from hexanes, triturated with hexanes, filtered and dried in vacuo to provide 25 mg (70%) of desired product as the trihydrochloride salt. MS ESI (+) m/z 362 (M+1) detected.

Aufarbeitung

  1. concentrationThe reaction was concentrated under reduced pressure
  2. customThe residue was evaporated from twice from toluene
  3. customonce from hexanes, triturated with hexanes
  4. filtrationfiltered
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1c5a0bb870aa4330a9f256a841ca997d
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08575145B2

Notizen zur Reaktion

Wird geladen…