Methyl iodide → 4-Bromo-5,6-dimethylpyridin-2-ol

Reaktionsgleichung

[Br:1][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[NH:5][C:4](=[O:10])[CH:3]=1.CI.[C:13]([O-])([O-])=O.[K+].[K+]>>[Br:1][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[N:5]([CH3:13])[C:4](=[O:10])[CH:3]=1.[Br:1][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[NH:5][C:4](=[O:10])[CH:3]=1

Komponenten

Edukt 3

HCID 6328Methyl iodide

HCID 11430Potassium Carbonate

HCID 469162514-Bromo-5,6-dimethylpyridin-2-ol

Produkt 2

HCID 469162514-Bromo-5,6-dimethylpyridin-2-ol

HCID 66736202HCID 66736202, Verbindung

Versuchsvorschrift

4-bromo-1,5,6-trimethylpyridin-2(1H)-one was prepared by alkylation of 4-bromo-5,6-dimethylpyridin-2(1H)-one with methyl iodide using K2CO3 following a procedure analogous to that described in Example 59 Step 1. 4-bromo-5,6-dimethylpyridin-2(1H)-one was prepared following the procedure described in McElroy, W. T. and DeShong, P. Org. Lett. 2003, 5, 4779.