Phthalimide → HCID 58459111, Verbindung

HRID 2036561Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2036561
[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[C:10]([Cl:11])[C:5]2=[N:4][C:3]=1[CH2:12]Cl.[C:14]1(=[O:24])[NH:18][C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[C:10]([Cl:11])[C:5]2=[N:4][C:3]=1[CH2:12][N:18]1[C:14](=[O:24])[C:15]2[C:16](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:17]1=[O:19]

Komponenten

5

Edukt 3

HCID 6809PhthalimideHCID 11430Potassium CarbonateHCID 58459174HCID 58459174, Verbindung

Produkt 1

HCID 58459111HCID 58459111, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

DMF (4.6 ml) was added to a mixture of 3-bromo-8-chloro-2-(chloromethyl)imidazo[1,2-a]pyridine (258 mg, 0.922 mmol), phthalimide (136 mg, 0.922 mmol) and K2CO3 (55.6 μL, 0.922 mmol). The reaction was heated at 80° C. After the reaction was complete, the mixture was initially partitioned between EtOAc and water, but the product did not dissolve readily. The product was collected by filteration of the mixture to give 2-((3-bromo-8-chloroimidazo[1,2-a]pyridin-2-yl)methyl)isoindoline-1,3-dione as a white solid.

Aufarbeitung

  1. customthe mixture was initially partitioned between EtOAc and water
  2. dissolutionthe product did not dissolve readily
  3. customThe product was collected by filteration of the mixture

Quellen und Nachweise

ORD-Eintrag
ord-b6227c1a9e044234b09e621056089cf0
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08575183B2

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