Aminopyridazine → (1-Imidazo[1,2-b]pyridazin-2-yl-ethyl)-carbamic acid benzyl ester

HRID 2036655Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2036655
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH2:7])[N:2]=1.[CH2:8]([O:15][C:16](=[O:24])[NH:17][CH:18]([CH3:23])[C:19](=O)[CH2:20]Br)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>CCO>[CH2:8]([O:15][C:16](=[O:24])[NH:17][CH:18]([C:19]1[N:7]=[C:3]2[CH:4]=[CH:5][CH:6]=[N:1][N:2]2[CH:20]=1)[CH3:23])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Komponenten

4

Edukt 2

HCID 230373AminopyridazineHCID 73196234Benzyl (4-bromo-3-oxobutan-2-yl)carbamate

Produkt 1

HCID 67433032(1-Imidazo[1,2-b]pyridazin-2-yl-ethyl)-carbamic acid benzyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of pyridazin-3-ylamine (2 g, 21.05 mmol) and (3-bromo-1-methyl-2-oxopropyl)-carbamic acid benzyl ester (7.5 g, 25.26 mmol) in EtOH (25 mL) was heated to reflux overnight. After completion, the reaction mixture was cooled to rt. EtOH was removed in vacuo. The residue was dissolved in EtOAc. The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo. The crude product was purified by column chromatography using silica gel (100-200 mesh) and 0-5% MeOH in DCM to provide (1-imidazo[1,2-b]pyridazin-2-yl-ethyl)-carbamic acid benzyl ester: LC-MS (ESI) m/z 297.3 [M+H]+.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customEtOH was removed in vacuo
  4. dissolutionThe residue was dissolved in EtOAc
  5. dry with materialThe organic layer was dried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo
  8. customThe crude product was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-39e76ec047ac4006adff339bc5247f70
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08575183B2

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