Hydrochloric Acid → N-Hydroxy-2-(pyridin-2-ylacetyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide hydrochloride

HRID 2036874Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2036874
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([N:10]1[CH2:19][CH2:18][C:17]2[C:12](=[CH:13][C:14]([C:20]([NH:22][O:23]C3CCCCO3)=[O:21])=[CH:15][CH:16]=2)[CH2:11]1)=[O:9].[ClH:30]>CO>[ClH:30].[OH:23][NH:22][C:20]([C:14]1[CH:13]=[C:12]2[C:17]([CH2:18][CH2:19][N:10]([C:8](=[O:9])[CH2:7][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)[CH2:11]2)=[CH:16][CH:15]=1)=[O:21]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 866566122-(pyridin-2-ylacetyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide

Produkt 1

HCID 86656611N-Hydroxy-2-(pyridin-2-ylacetyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 130 mg 2-(pyridin-2-ylacetyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide in 6 ml methanol and 6 ml 0.1 N aqueous hydrochloric acid is stirred overnight at ambient temperature. Subsequently, the reaction mixture is evaporated. The residue is dissolved in a mixture of water and acetonitrile and lyophilized. 105 mg of the title compound are obtained. MH+=312.1

Aufarbeitung

  1. customSubsequently, the reaction mixture is evaporated
  2. dissolutionThe residue is dissolved in a mixture of water and acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-01cb2db50c2447c795fdd82465c299a6
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08575193B2

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