Phosphorus oxychloride → 2-Chloro-4-phenylthiazole

Reaktionsgleichung

[C:1]1([C:7]2[NH:8][C:9](=O)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O=P(Cl)(Cl)[Cl:15]>>[Cl:15][C:9]1[S:10][CH:11]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:8]=1

Komponenten

Edukt 2

HCID 24813Phosphorus oxychloride

HCID 6989032-Hydroxy-4-phenylthiazole

Produkt 1

HCID 27613592-Chloro-4-phenylthiazoleAusbeute 57 %

Versuchsvorschrift

4-Phenyl-3H-thiazol-2-one (5 g, 28.2 mmol) was dissolved in POCl3 (30 mL), and the mixture was refluxed overnight. The mixture was concentrated in vacuum, and the residue was purified by column chromatography to give 2-chloro-4-phenylthiazole (3.1 g, 57%).

Aufarbeitung

temperaturethe mixture was refluxed overnight
concentrationThe mixture was concentrated in vacuum
customthe residue was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag: ord-1cc5365b28cf420f811c50c15b2f1e98
Quelldatensatz: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08575156B2

Notizen zur Reaktion

Wird geladen…