Dichloromethane → 1-[5-(1-Methyl-1H-pyrazol-4-yl)-pyridin-2-yl]-cyclopropylamine dihydrochloride

HRID 2038773Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2038773
C(OC(=O)[NH:7][C:8]1([C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[N:19][N:20]([CH3:22])[CH:21]=3)=[CH:13][N:12]=2)[CH2:10][CH2:9]1)(C)(C)C.O1CCOCC1.C(Cl)[Cl:31]>Cl>[ClH:31].[ClH:31].[CH3:22][N:20]1[CH:21]=[C:17]([C:14]2[CH:15]=[CH:16][C:11]([C:8]3([NH2:7])[CH2:10][CH2:9]3)=[N:12][CH:13]=2)[CH:18]=[N:19]1

Komponenten

5

Edukt 3

HCID 6344DichloromethaneHCID 312751,4-Dioxane2×HCID 67515892{1-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-2-yl]-cyclopropyl}-carbamic acid tert-butyl ester

Produkt 1

HCID 683794491-[5-(1-Methyl-1H-pyrazol-4-yl)-pyridin-2-yl]-cyclopropylamine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel2×

Versuchsvorschrift

To a solution of {1-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-2-yl]-cyclopropyl}-carbamic acid tert-butyl ester (1.1 g, 3.5 mmol) in CH2Cl2 (15 mL), 4.0M HCl in dioxane (4.35 mL, 17.5 mmol) was added. After stirring overnight, more 4.0M HCl in dioxane (4.35 mL, 17.5 mmol) was added to the solution. After another 12 hours, the solution was concentrated in-vacuo to yield 800 mg of the title compound.

Aufarbeitung

  1. waitAfter another 12 hours
  2. concentrationthe solution was concentrated in-vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6dfe18c96a90465fad0bb0cc843bf65a
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08575360B2

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