6-Phenylpyrimidin-4-amine → HCID 23633266, Verbindung
Reaktionsgleichung
[C:1]([C:5]1[N:10]=[CH:9][N:8]=[C:7]([NH:11][C:12](=[O:30])[NH:13][C:14]2[CH:29]=[CH:28][C:17]([O:18][C:19]3[CH:24]=[CH:23][N:22]=[C:21]([C:25](=[S:27])[NH2:26])[CH:20]=3)=[CH:16][CH:15]=2)[CH:6]=1)([CH3:4])([CH3:3])C.N[C:32]1N=CN=[C:34](C2C=CC=CC=2)[CH:33]=1>>[C:1]1([C:5]2[N:10]=[CH:9][N:8]=[C:7]([NH:11][C:12](=[O:30])[NH:13][C:14]3[CH:15]=[CH:16][C:17]([O:18][C:19]4[CH:24]=[CH:23][N:22]=[C:21]([C:25](=[S:27])[NH2:26])[CH:20]=4)=[CH:28][CH:29]=3)[CH:6]=2)[CH:3]=[CH:34][CH:33]=[CH:32][CH:4]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared in the same manner as described for 4-{-4-[3-(6-tert-butylpyrimidin-4-yl)ureido]phenoxy}pyridine-2-carbothioic acid amide, replacing 6-amino-4-tert-butylpyrimidine for 6-amino-4-phenylpyrimidine. 1H-NMR (DMSO-d6) δ 10.18 (broad s, 1H), 10.04 (broad s, 1H), 9.91 (broad s, 1H), 9.85 (broad s, 1H), 8.78 (d, J=1.2 Hz, 1H), 8.45 (d, J=5.7 Hz, 1H), 8.15 (s, 1H), 8.06 to 8.02 (m, 2H), 7.94 (d, J=2.7 Hz, 1H), 7.64 (d, J=8.7 Hz, 2H), 7.54 to 7.52 (m, 3H), 7.20 (d, J=8.7 Hz, 2H), 7.12 (dd, J=5.7, 3.0 Hz, 1H); LC-MS m/z 443 [M+H]+, RT=3.19 min.
Quellen und Nachweise
- ORD-Eintrag
- ord-6cfeed6164194c15a0b3be8ae91c5c7a
- Quelldatensatz
- uspto-grants-2013_11