Triethylamine → Benzyl (R)-3-(2-benzyloxycarbonylaminoethylsulfanyl)-2-[3-((9S,12R)-9-isopropyl-11-oxo-2,7-dioxa-10-azabicyclo[12.2.2]octadeca-1(17),14(18),15-trien-12-yl)ureido]propionate

HRID 2040005Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2040005
[C:1](N1C=CN=C1)(N1C=CN=C1)=[O:2].[NH2:13][C@@H:14]([CH2:25][S:26][CH2:27][CH2:28][NH:29][C:30]([O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:31])[C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16].C(N(CC)CC)C.[NH2:47][C@@H:48]1[CH2:63][C:62]2=[CH:64][CH:65]=[C:59]([CH:60]=[CH:61]2)[O:58][CH2:57][CH2:56][CH2:55][CH2:54][O:53][CH2:52][C@H:51]([CH:66]([CH3:68])[CH3:67])[NH:50][C:49]1=[O:69]>CN(C=O)C>[CH2:33]([O:32][C:30]([NH:29][CH2:28][CH2:27][S:26][CH2:25][C@H:14]([NH:13][C:1]([NH:47][C@@H:48]1[CH2:63][C:62]2=[CH:61][CH:60]=[C:59]([CH:65]=[CH:64]2)[O:58][CH2:57][CH2:56][CH2:55][CH2:54][O:53][CH2:52][C@H:51]([CH:66]([CH3:67])[CH3:68])[NH:50][C:49]1=[O:69])=[O:2])[C:15]([O:17][CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:16])=[O:31])[C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1

Komponenten

6

Edukt 4

HCID 8471TriethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 58360483(9S,12R)-12-Amino-9-isopropyl-2,7-dioxa-10-azabicyclo[12.2.2]octadeca-1(17),14(18),15-trien-11-oneHCID 58360484Benzyl (R)-2-amino-3-(2-benzyloxycarbonylaminoethylsulfanyl)propionate

Produkt 1

HCID 67320524Benzyl (R)-3-(2-benzyloxycarbonylaminoethylsulfanyl)-2-[3-((9S,12R)-9-isopropyl-11-oxo-2,7-dioxa-10-azabicyclo[12.2.2]octadeca-1(17),14(18),15-trien-12-yl)ureido]propionateAusbeute 29,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel2×

Versuchsvorschrift

A solution of 166 mg (1.02 mmol) of 1,1′-carbonyldiimidazole in 8 ml of DMF was mixed with 515 mg (1.02 mmol) of the trifluoroacetate from step B and 0.57 ml (415 mg, 4.10 mmol) of triethylamine. A solution of 328 mg (1.02 mmol) of (9S,12R)-12-amino-9-isopropyl-2,7-dioxa-10-azabicyclo[12.2.2]octadeca-1(17),14(18),15-trien-11-one (1-1E) in 8 ml of DMF was added to this mixture under argon, and the mixture was stirred at RT overnight. The reaction mixture was then concentrated and separated by preparative HPLC. The required fractions were combined and freed of acetonitrile. The resulting aqueous solution was extracted with ethyl acetate, and the organic phase was dried over sodium sulfate, filtered and concentrated. 222 mg of the title compound were obtained.

Aufarbeitung

  1. concentrationThe reaction mixture was then concentrated
  2. customseparated by preparative HPLC
  3. extractionThe resulting aqueous solution was extracted with ethyl acetate
  4. dry with materialthe organic phase was dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-4cc18421303540ec8d21be5d383db529
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08580777B2

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