4-[3-(Dimethylamino)propoxy]benzonitrile → 4-[3-(Dimethylamino)propoxy]benzylamine

HRID 2040210Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2040210
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=1>CO.[Ni]>[NH2:12][CH2:11][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][CH2:4][CH2:3][N:2]([CH3:1])[CH3:15])=[CH:14][CH:13]=1

Komponenten

4

Edukt 1

HCID 118583624-[3-(Dimethylamino)propoxy]benzonitrile

Produkt 1

HCID 214653844-[3-(Dimethylamino)propoxy]benzylamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

4-(3-(Dimethylamino)propoxy)benzonitrile (300 mg) in methanol (20 mL) was treated with Raney nickel (wet, 1.5 g) under H2 (30 psi) for 4 hour. The insoluble material was filtered off and the filtrate was concentrated to provide the title compound.

Aufarbeitung

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-b7b04f4deecc4e139729fe242186fe1b
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08580794B2

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