3-[(3-Chlorophenyl)ethynyl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-one → 3-(2-Phenylethynyl)-1-oxa-2-azaspiro[4.5]dec-2-en-8-one

HRID 2040872Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2040872
Cl[C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH2:19][CH2:18][C:17](=[O:20])[CH2:16][CH2:15]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1.C1(C#CC2CC3(CCC4(OCCO4)CC3)ON=2)C=CC=CC=1>>[C:4]1([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH2:19][CH2:18][C:17](=[O:20])[CH2:16][CH2:15]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=1

Komponenten

3

Edukt 2

HCID 566464673-[(3-Chlorophenyl)ethynyl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-oneHCID 56646683HCID 56646683, Verbindung

Produkt 1

HCID 566466843-(2-Phenylethynyl)-1-oxa-2-azaspiro[4.5]dec-2-en-8-one

Versuchsvorschrift

The title compound was synthesized using the same method described for the compound of Example 32, but starting from the compound of Example 44 instead of the compound of Example 31. The crude was purified by automated flash chromatography (SP1®TM-Biotage; Petroleum Ether-EtOAc 8:2) to give the title product as white solid. Yield: 80%.

Aufarbeitung

  1. customThe title compound was synthesized
  2. customThe crude was purified by automated flash chromatography (SP1®TM-Biotage; Petroleum Ether-EtOAc 8:2)

Quellen und Nachweise

ORD-Eintrag
ord-3bf756c993954164bdc2a7b6f407dfbc
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08580962B2

Notizen zur Reaktion

Wird geladen…