1,4-Dioxaspiro[4.5]decan-8-one → HCID 57493861, Verbindung

HRID 2040895Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2040895
[CH2:1]=C1CCC2(OCCO2)CC1.O=[C:13]1[CH2:18][CH2:17][C:16]([C:24]([O:26][CH2:27][CH3:28])=[O:25])([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:15][CH2:14]1.O1C2(CCC(=O)CC2)OCC1>>[CH2:1]=[C:13]1[CH2:18][CH2:17][C:16]([C:24]([O:26][CH2:27][CH3:28])=[O:25])([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:15][CH2:14]1

Komponenten

4

Edukt 3

HCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 27760711,1-Diethyl 4-oxocyclohexane-1,1-dicarboxylateHCID 109537438-Methylidene-1,4-dioxaspiro[4.5]decane

Produkt 1

HCID 57493861HCID 57493861, Verbindung

Versuchsvorschrift

The title compound was prepared following the method reported herein for Compound 31a. As starting material diethyl 4-oxocyclohexane-1,1-dicarboxylate replaced 1,4-dioxaspiro[4.5]decan-8-one. After the usual work-up procedure the residue was purified by means of automated flash chromatography (SP01®TM-Biotage; gradient Petroleum Ether-EtOAc from 1:0 to 8:2) to give the title compound as a colorless oil. Yield: 88.1%.

Aufarbeitung

  1. customThe title compound was prepared
  2. customAfter the usual work-up procedure the residue was purified by means of automated flash chromatography (SP01®TM-Biotage; gradient Petroleum Ether-EtOAc from 1:0 to 8:2)

Quellen und Nachweise

ORD-Eintrag
ord-ce9b68e9d5184dab83e15f0b540b686b
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08580962B2

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