Reaktionsgleichung
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH:13]2[CH:17](O)[CH2:16][N:15]([CH3:19])[C:14]2=[O:20])=[CH:4][CH:3]=1>ClCCl>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[C@@H:13]3[C:14](=[O:20])[N:15]([CH3:19])[CH2:16][C@@H:17]3[C:4]=2[CH:3]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 110 °C
Versuchsvorschrift
A mixture of 3 g (9.4 mmol) of 3-[2-(4-chlorophenoxy)phenyl]-4-hydroxy-1-methylpyrrolidine-2-one (compound XIIIb) and 40 g of polyphosphoric acid was stirred overnight at 110° C. After cooling down to room temperature, the resulting mixture was poured into 150 mL of an ice-water mixture. 100 mL of dichloromethane were added, and the organic phase was extracted. The aqueous phase was washed with 50 mL of dichloromethane. The organic phases were combined, washed with brine, and evaporated under vacuum. The crude product was purified by column chromatography to obtain 0.5 g of cis-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one (compound cis-VIb). Yield: 17.7%.
Aufarbeitung
- temperatureAfter cooling down to room temperature
- extractionthe organic phase was extracted
- washThe aqueous phase was washed with 50 mL of dichloromethane
- washwashed with brine
- customevaporated under vacuum
- customThe crude product was purified by column chromatography
Quellen und Nachweise
- ORD-Eintrag
- ord-3a05f1c2840f4af4a9c91fc97f2207ac
- Quelldatensatz
- uspto-grants-2013_11
- Patentnummer
- US08580972B2
Verknüpfte Notizen
Wird geladen…