Potassium Carbonate → 6-[(benzothiazol-6-yl-methyl)-amino]-7-chloro-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

https://huagongshe.com/reaction/2041280

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Potassium Carbonate	HCID 11430	—
Edukt	6-(Bromomethyl)benzo[d]thiazole	HCID 53406993	—
Edukt	6-Amino-7-chloro-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine	HCID 57656292	—
Lösungsmittel	Dimethylformamide	HCID 6228	—
Produkt	6-[(benzothiazol-6-yl-methyl)-amino]-7-chloro-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine	HCID 86629633	—

Reaktionsbedingungen

Temperatur	150 °C

Reaktionsschritte

Using a method similar to the General Procedure 5-4, combine 6-amino-7-chloro-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (0.1 g, 0.35 mmol), 6-bromomethyl-benzothiazole (80 mg, 0.35 mmol), and potassium carbonate (47.0 mg, 0.35 mmol) in anhydrous DMF (1 mL) in a sealed tube. Heat at 150° C. for 3 h to obtain 6-[(benzothiazol-6-yl-methyl)-amino]-7-chloro-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine as a colorless oil.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08580780B2
Quelldatensatz	uspto-grants-2013_11
ORD ID	ord-70b19a46370243cba023ccc20eba8007
Quellennotiz	uspto-grants-2013_11