Isopropanol → Estradiol; Norethindrone Acetate

HRID 2041805

Reaktionsgleichung

Reaktionsgleichung von HRID 2041805
[CH:1]([OH:4])(C)[CH3:2].[CH3:5][CH2:6][CH:7]([O:9]C(C)=O)[CH3:8].CC(O)COC(CO)C.[C:22]([OH:41])(=O)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]/[CH:30]=[CH:31]\[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39].[C:42]([O:45][CH2:46][CH3:47])(=[O:44])[CH3:43]>C(O)C.C1(C)C=CC=CC=1>[CH3:39][C@@:38]12[C@@H:22]([OH:41])[CH2:23][CH2:24][C@H:25]1[C@H:26]1[C@@H:35]([C:34]3[CH:33]=[CH:32][C:31]([OH:4])=[CH:30][C:29]=3[CH2:28][CH2:27]1)[CH2:36][CH2:37]2.[CH3:43][C:42]([O:45][C@:46]1([C:1]#[CH:2])[C@@:29]2([CH3:28])[CH2:30][CH2:31][C@@H:32]3[C@@H:33]4[C:34](=[CH:8][C:7]([CH2:6][CH2:5]4)=[O:9])[CH2:35][CH2:36][C@H:37]3[C@@H:38]2[CH2:39][CH2:47]1)=[O:44]

Komponenten

9

Edukt 6

HCID 3776IsopropanolHCID 7758Sec-Butyl acetateHCID 8857Ethyl AcetateHCID 328812-(2-Hydroxypropoxy)-1-propanolHCID 445639Oleic AcidHCID 178527255HCID 178527255, Verbindung

Produkt 1

HCID 3045253Estradiol; Norethindrone Acetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 1140TolueneLösungsmittel2×

Versuchsvorschrift

An estradiol/norethindrone acetate pressure-sensitive adhesive mixture was prepared by combining 5.68 grams of a polyoxazoline polymer [Aquazol® 50] with 5.68 grams of isopropyl alcohol and 5.71 grams of toluene. Then 66.41 grams of a polysiloxane adhesive (BIO-PSA®-4603, trimethylated silica treatment with dimethyl siloxane in toluene; Dow Corning Corporation, Medical Products, Midland, Mich.), 8.74 grams of a polyacrylate adhesive (Gelva® 737, an acrylic resin in ethyl acetate, ethanol and toluene; Surface Specialties, Springfield, Mass.), 2.27 grams of dipropylene glycol and 3.41 grams of oleic acid were added as co-solvents and enhancers, and thoroughly mixed in an appropriate container until the mixture was completely homogeneous. The resulting composition had the ingredient concentrations on a dry weight percent basis (i.e., after evaporation of the volatile solvents) as shown below.

Aufarbeitung

  1. additionthoroughly mixed in an appropriate container until the mixture
  2. concentrationthe ingredient concentrations on a dry weight percent basis (i.e.
  3. customafter evaporation of the volatile solvents)

Quellen und Nachweise

ORD-Eintrag
ord-2e4853dc6e2c47d18a1eb57a640cdeed
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08586080B1

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