Hydrochloric Acid → HCID 53409533, Verbindung

HRID 2041964Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2041964
[C:1]([C:5]1[CH:23]=[CH:22][CH:21]=[CH:20][C:6]=1[O:7][CH:8]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[ClH:24]>O1CCOCC1>[ClH:24].[C:1]([C:5]1[CH:23]=[CH:22][CH:21]=[CH:20][C:6]=1[O:7][CH:8]1[CH2:12][CH2:11][NH:10][CH2:9]1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 59577147HCID 59577147, Verbindung

Produkt 1

HCID 53409533HCID 53409533, VerbindungAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A stirred solution of tert-butyl 3-(2-tert-butylphenoxy)pyrrolidine-1-carboxylate (0.78 g, 2.44 mmol) and hydrochloric acid (7.0 mL of a 4.0 N solution in dioxane, 28.0 mmol) was reacted at room temperature for 16 h. Then, the reaction mixture was concentrated under reduced pressure. The residue was triturated with ethyl acetate to provide 3-(2-tert-butylphenoxy)pyrrolidine hydrochloride as a colorless solid (0.52 g, 83%).

Aufarbeitung

  1. concentrationThen, the reaction mixture was concentrated under reduced pressure
  2. customThe residue was triturated with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-f014bae3f44241d68b139b214acb94e5
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08586571B2

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