Hydrochloric Acid → N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride

HRID 2042241Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2042241
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[N:14]=[CH:13][C:12]([NH:15][C:16]3[N:17]=[CH:18][C:19]4[S:24][CH:23]=[C:22]([C:25]5[CH:26]=[C:27]([NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[CH:28]=[CH:29][CH:30]=5)[C:20]=4[N:21]=3)=[CH:11][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].[ClH:36]>O1CCCC1.O1CCOCC1>[ClH:36].[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[N:14]=[CH:13][C:12]([NH:15][C:16]3[N:17]=[CH:18][C:19]4[S:24][CH:23]=[C:22]([C:25]5[CH:26]=[C:27]([NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[CH:28]=[CH:29][CH:30]=5)[C:20]=4[N:21]=3)=[CH:11][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 51347359N-(3-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

Produkt 1

HCID 52932127N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

N-(3-(2-(6-(4-Ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide (300 mg, 0.589 mmol) was dissolved in tetrahydrofuran (5 mL) and then 4 M hydrogen chloride (147 μL) dissolved in dioxane was added at room temperature. 30 minutes later, thus prepared precipitate was filtered and dried at room temperature. The target compound N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride (305 mg) was yielded.

Aufarbeitung

  1. additionwas added at room temperature
  2. filtration30 minutes later, thus prepared precipitate was filtered
  3. customdried at room temperature

Quellen und Nachweise

ORD-Eintrag
ord-2a4a0428de054373bcbeb2390b50480c
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08586580B2

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