Pivaloyl chloride → N-(3-Nitro-2,4-dichloro-benzyl)-2,2-dimethyl-propionamide

HRID 2042786Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2042786
[CH3:1][C:2]([CH3:7])([CH3:6])[C:3](Cl)=[O:4].[N+:8]([C:11]1[C:12]([Cl:20])=[C:13]([CH:16]=[CH:17][C:18]=1[Cl:19])[CH2:14][NH2:15])([O-:10])=[O:9]>C1COCC1>[N+:8]([C:11]1[C:12]([Cl:20])=[C:13]([CH:16]=[CH:17][C:18]=1[Cl:19])[CH2:14][NH:15][C:3](=[O:4])[C:2]([CH3:7])([CH3:6])[CH3:1])([O-:10])=[O:9]

Komponenten

4

Edukt 2

HCID 62493Pivaloyl chlorideHCID 56839971(2,4-Dichloro-3-nitrophenyl)methanamine

Produkt 1

HCID 67958116N-(3-Nitro-2,4-dichloro-benzyl)-2,2-dimethyl-propionamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2,2-Dimethyl-propionic acid chloride (0.124 mL, 1.01 mmol) is added to a mixture of 3-nitro-2,4-dichloro-benzylamine (0.28 g, 1.01 mmol) and TEA (0.35 mL, 2.52 mmol) in THF (10 mL) and it is stirred overnight. The reaction mixture is concentrated, diluted with EtOAc, washed successively with 5% aq. NaHCO3 solution and brine, dried with Na2SO4 filtered and concentrated.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated
  2. additiondiluted with EtOAc
  3. washwashed successively with 5% aq. NaHCO3 solution and brine
  4. dry with materialdried with Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-a6e5ba0dd04c4ab4af39ebc12a93261a
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08586604B2

Notizen zur Reaktion

Wird geladen…