Sodium Hydroxide → 3-Nitro-2,4-dimethyl-benzylamine

HRID 2042799

Reaktionsgleichung

Reaktionsgleichung von HRID 2042799
[N+:1]([C:4]1[C:5]([CH3:19])=[C:6]([CH:15]=[CH:16][C:17]=1[CH3:18])[CH2:7][NH:8]C(=O)C(F)(F)F)([O-:3])=[O:2].[OH-].[Na+]>CO>[N+:1]([C:4]1[C:5]([CH3:19])=[C:6]([CH:15]=[CH:16][C:17]=1[CH3:18])[CH2:7][NH2:8])([O-:3])=[O:2]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 56840191N-(3-Nitro-2,4-dimethyl-benzyl)-2,2,2-trifluoroacetamide

Produkt 1

HCID 568399723-Nitro-2,4-dimethyl-benzylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of N-(3-nitro-2,4-dimethyl-benzyl)-2,2,2-trifluoroacetamide (1.53 g, 5.54 mmol), 4M NaOH-solution (6.9 mL, 28 mmol) and MeOH (30 mL) is refluxed for 2 h. Then the mixture is concentrated, diluted with water and extracted with EtOAc. The organic phase is dried with Na2SO4, filtered and concentrated.

Aufarbeitung

  1. temperatureis refluxed for 2 h
  2. concentrationThen the mixture is concentrated
  3. additiondiluted with water
  4. extractionextracted with EtOAc
  5. dry with materialThe organic phase is dried with Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-6d1baf858ea74d8c8a1442eea1d634b1
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08586604B2

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