Pivaloyl chloride → N-(4-Chloro-3-nitrobenzyl)-2,2-dimethyl-propionamide

HRID 2042811Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2042811
[C:1](Cl)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[Cl:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][NH2:14])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]>C1COCC1>[Cl:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][NH:14][C:1](=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Komponenten

4

Edukt 2

HCID 62493Pivaloyl chlorideHCID 18796740(4-Chloro-3-nitrophenyl)methanamine

Produkt 1

HCID 66765017N-(4-Chloro-3-nitrobenzyl)-2,2-dimethyl-propionamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel3×

Versuchsvorschrift

TEA (8.00 mL, 57.5 mmol) followed by pivaloyl chloride (2.80 mL, 22.8 mmol) in THF (25 mL) are added to 4-chloro-3-nitrobenzylamine (5.00 g) in THF (100 mL). The reaction mixture is diluted with THF and stirred at rt for 1.5 h. The mixture is filtered and washed and the filtrate is concentrated.

Aufarbeitung

  1. filtrationThe mixture is filtered
  2. washwashed
  3. concentrationthe filtrate is concentrated

Quellen und Nachweise

ORD-Eintrag
ord-82f6152cfeb04c0cbbad98eea7d5d7ae
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08586604B2

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