Acetonitrile → N-(4-Chloro-3-{[3-(4-bromo-phenylcarbamoyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-pyridin-2-yl]-thioureido}-benzyl)-2,2-dimethyl-propionamide

HRID 2042812Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2042812
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][NH:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:4][C:3]=1[N:16]=[C:17]=[S:18].N[C:20]1[C:21]([NH:41][CH3:42])=[N:22][C:23]([O:36][CH2:37][CH:38]([F:40])[F:39])=[C:24]([CH:35]=1)[C:25]([NH:27][C:28]1[CH:33]=[CH:32][C:31]([Br:34])=[CH:30][CH:29]=1)=[O:26].CC#[N:45]>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][NH:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:4][C:3]=1[NH:16][C:17]([NH:45][C:23]1([O:36][CH2:37][CH:38]([F:40])[F:39])[C:24]([C:25](=[O:26])[NH:27][C:28]2[CH:33]=[CH:32][C:31]([Br:34])=[CH:30][CH:29]=2)=[CH:35][CH:20]=[C:21]([NH:41][CH3:42])[NH:22]1)=[S:18]

Komponenten

4

Edukt 3

HCID 6342AcetonitrileHCID 86646343HCID 86646343, VerbindungHCID 866648925-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide

Produkt 1

HCID 86669292N-(4-Chloro-3-{[3-(4-bromo-phenylcarbamoyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-pyridin-2-yl]-thioureido}-benzyl)-2,2-dimethyl-propionamide

Versuchsvorschrift

N-(4-Chloro-3-isothiocyanatobenzyl)-2,2-dimethyl-propionamide (66 mg, 0.23 mmol) is added to 5-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide (93 mg, 0.23 mmol) in MeCN (3.5 mL) and stirred at rt overnight. The reaction mixture is filtered and the filtercake is dried.

Aufarbeitung

  1. filtrationThe reaction mixture is filtered
  2. customthe filtercake is dried

Quellen und Nachweise

ORD-Eintrag
ord-1552cf0d52a247f295881565a93008dc
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08586604B2

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