Diisopropylcarbodiimide → HCID 178481212, Verbindung

HRID 2042819Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2042819
CC(C)N=C=NC(C)C.[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][NH:16][C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:13][C:12]=1[NH:25][C:26]([NH:28][C:29]1[CH:30]=[C:31]([C:42](=[O:54])[NH:43][C@H:44]2[CH2:49][CH2:48][C@H:47]([C:50]([F:53])([F:52])[F:51])[CH2:46][CH2:45]2)[C:32]([O:37][CH2:38][CH:39]([F:41])[F:40])=[N:33][C:34]=1[NH:35][CH3:36])=S>CC#N>[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][NH:16][C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:13][C:12]=1[NH:25][C:26]1[N:35]([CH3:36])[C:34]2=[N:33][C:32]([O:37][CH2:38][CH:39]([F:41])[F:40])=[C:31]([C:42](=[O:54])[NH:43][C@H:44]3[CH2:49][CH2:48][C@H:47]([C:50]([F:53])([F:52])[F:51])[CH2:46][CH2:45]3)[CH:30]=[C:29]2[N:28]=1

Komponenten

4

Edukt 2

HCID 12734DiisopropylcarbodiimideHCID 178482446HCID 178482446, Verbindung

Produkt 1

HCID 178481212HCID 178481212, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

DIC (40 μL, 0.24 mmol) is added to a mixture of N-{4-chloro-3-[3-(trans-4-trifluoromethyl-cyclohexylcarbamoyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-pyridin-5-ylthioureido]benzyl}-2,2-dimethyl-propionamide (135 mg, 0.20 mmol) and MeCN (3.5 mL). The reaction mixture is stirred at 60° C. overnight, allowed to cool and concentrated. The residue is treated with MeCN, filtered off and dried.

Aufarbeitung

  1. temperatureto cool
  2. concentrationconcentrated
  3. additionThe residue is treated with MeCN
  4. filtrationfiltered off
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-f6849ae1aa4b41d5924c0b797305cc8f
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08586604B2

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