O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 178508983, Verbindung

HRID 2042837Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2042837
[F:1][C:2]([F:11])([F:10])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH2:9])[CH2:5][CH2:4]1.[OH:12][CH2:13][CH2:14][O:15][C:16]1[N:24]=[C:23]([NH2:25])[C:22]([N+:26]([O-:28])=[O:27])=[CH:21][C:17]=1[C:18](O)=[O:19].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>>[F:1][C:2]([F:10])([F:11])[C@H:3]1[CH2:4][CH2:5][C@H:6]([NH:9][C:18](=[O:19])[C:17]2[CH:21]=[C:22]([N+:26]([O-:28])=[O:27])[C:23]([NH2:25])=[N:24][C:16]=2[O:15][CH2:14][CH2:13][OH:12])[CH2:7][CH2:8]1

Komponenten

4

Edukt 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 667651902-(2-Hydroxy-ethoxy)-6-amino-5-nitro-nicotinic acidHCID 178511531HCID 178511531, Verbindung

Produkt 1

HCID 178508983HCID 178508983, Verbindung

Versuchsvorschrift

trans-4-Trifluoromethyl-cyclohexylamine (285 mg, 1.40 mmol) and TEA (410 μl) are added successively to a mixture of 2-(2-hydroxy-ethoxy)-6-amino-5-nitro-nicotinic acid (360 mg, 1.33 mmol), TBTU (285 mg, 1.33 mmol) and TEA (195 μl) and it is stirred for 1.5 h. The mixture is concentrated filtered and purified via chromatography.

Aufarbeitung

  1. concentrationThe mixture is concentrated
  2. filtrationfiltered
  3. custompurified via chromatography

Quellen und Nachweise

ORD-Eintrag
ord-7bf69942637d43a795079e17577c6810
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08586604B2

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