Dimethylformamide → [1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide

HRID 2043

Reaktionsgleichung

Reaktionsgleichung von HRID 2043
[Na].[N:2]1([C:13](=[O:14])[C:12]2[NH:11][CH:10]=[N:9][C:8]=2[N:6]([CH3:7])[C:4]1=[O:5])[CH3:3].Cl[CH2:16][P:17](=[O:20])(C)[CH3:18].[CH3:21]N(C=O)C>>[CH3:7][N:6]1[C:8]2[N:9]=[CH:10][N:11]([CH3:21])[C:12]=2[C:13](=[O:14])[N:2]([CH2:3][P:17](=[O:20])([CH3:18])[CH3:16])[C:4]1=[O:5]

Komponenten

4

Edukt 3

HCID 6228DimethylformamideHCID 74224Phosphine oxide, (chloromethyl)dimethyl-HCID 669736033,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, sodium salt

Produkt 1

HCID 19689229[1-(3,7-Dimethylxanthin-1-yl)methyl]dimethylphosphine Oxide

Versuchsvorschrift

A solution of 20.2 g (0.1 mol) of theophylline sodium salt in 400 ml of DMF was heated at 130° C. for 3 hours with 12.7 g of chloromethyldimethyl-phosphine oxide. The solution was filtered, the solvent was evaporated and the residue was taken up in methanol. The precipitate was filtered off and dried to constant weight under reduced pressure.

Aufarbeitung

  1. filtrationThe solution was filtered
  2. customthe solvent was evaporated
  3. filtrationThe precipitate was filtered off
  4. customdried to constant weight under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3604df54e33345c3b923bde3a99dbbb6
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05728686

Verknüpfte Notizen

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