Hydrochloric Acid → 4-(Hydroxymethyl)-4-piperidinol hydrochloride

HRID 2043443Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2043443
C([N:8]1[CH2:13][CH2:12][C:11]([CH2:15][OH:16])([OH:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.[ClH:17]>C(O)C.[C].[Pd]>[ClH:17].[OH:16][CH2:15][C:11]1([OH:14])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 140253361-Benzyl-4-(hydroxymethyl)piperidin-4-ol

Produkt 1

HCID 227444724-(Hydroxymethyl)-4-piperidinol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

500 mg of 1-benzyl-4-(hydroxymethyl)piperidin-4-ol (synthesized according to the method described in J. Med. Chem., 1988, 486-491) was dissolved in 10 ml of ethanol, 300 mg of 10% palladium carbon and 0.38 ml of concentrated hydrochloric acid were added thereto, and the mixture was subjected to hydrogenation at room temperature overnight. The reaction mixture was filtrated to remove precipitates, the precipitates were washed with ethanol and water, and the filtrate was concentrated under reduced pressure. The obtained residue was turned into powder by adding diethylether to obtain 374 mg of the objective compound as a white powder.

Aufarbeitung

  1. filtrationThe reaction mixture was filtrated
  2. customto remove
  3. customprecipitates
  4. washthe precipitates were washed with ethanol and water
  5. concentrationthe filtrate was concentrated under reduced pressure
  6. additionby adding diethylether

Quellen und Nachweise

ORD-Eintrag
ord-4e510fa01fb14463a48738b2380e3fd0
Quelldatensatz
uspto-grants-2013_11
Patentnummer
US08586591B2

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