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Phthalimide → 2-(1-(2,5-Dichloroquinolin-3-yl)ethyl)isoindoline-1,3-dione

HRID 2044877
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Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 2044877
S(Cl)(Cl)=O.[Cl:5][C:6]1[C:15]([CH:16](Cl)[CH3:17])=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[Cl:19])[N:7]=1.[C:20]1(=[O:30])[NH:24][C:23](=[O:25])[C:22]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:21]12.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Cl:5][C:6]1[C:15]([CH:16]([N:24]2[C:20](=[O:30])[C:21]3[C:22](=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:23]2=[O:25])[CH3:17])=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[Cl:19])[N:7]=1
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Komponenten

6

Edukt 4

HCID 6809PhthalimideHCID 11430Potassium CarbonateHCID 24386Thionyl ChlorideHCID 577080552,5-Dichloro-3-(1-chloroethyl)quinoline

Produkt 1

HCID 577078732-(1-(2,5-Dichloroquinolin-3-yl)ethyl)isoindoline-1,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228
Dimethylformamide
Lösungsmittel

Reaktionsbedingungen

Temperatur
55 °C

Versuchsvorschrift

Added thionyl chloride (301 μl, 4131 μmol). Obtained a clear colorless solution within minutes. Concentrated reaction mixture to dryness on the rotavap to obtain an oil, which was used without further purification. LC-MS (+esi, M+H+=260.0). Dissolved 2,5-dichloro-3-(1-chloroethyl)quinoline (215 mg, 825 μmol) in DMF (2 mL) and added phthalimide (127 mg, 866 μmol) and K2CO3 (228 mg, 1650 μmol). Submerged in oil bath and began heating to 55° C. After 10 min the temperature of the oil bath was raised to 80° C. After 30 more minutes the reaction mixture was partitioned between EtOAc:H2O. The organic layer was washed with water (3×), dried with sodium sulfate, filtered, and concentrated. The crude was solid was chromatographed on 12 g silica gel column with 0-20% EtOAc:Hex. The desired fractions were combined and concentrated to yield a white crystalline solid. 1H NMR (400 MHz, DICHLOROMETHANE-d2) δ ppm 1.99 (d, J=7.04 Hz, 3 H) 5.93 (q, J=7.17 Hz, 1 H) 7.64-7.70 (m, 2 H) 7.71-7.76 (m, 2 H) 7.77-7.83 (m, 2 H) 7.88-7.93 (m, 1 H) 8.95 (s, 1 H). LC-MS (+esi, M+H+=371.0)

Aufarbeitung

  1. customObtained a clear colorless solution within minutes
  2. concentrationConcentrated
  3. customreaction mixture to dryness on the rotavap
  4. customto obtain an oil, which
  5. customwas used without further purification
  6. customSubmerged in oil bath
  7. temperatureAfter 10 min the temperature of the oil bath was raised to 80° C
  8. customAfter 30 more minutes the reaction mixture was partitioned between EtOAc
  9. washThe organic layer was washed with water (3×)
  10. dry with materialdried with sodium sulfate
  11. filtrationfiltered
  12. concentrationconcentrated
  13. customwas chromatographed on 12 g silica gel column with 0-20% EtOAc
  14. concentrationconcentrated
  15. customto yield a white crystalline solid

Quellen und Nachweise

ORD-Eintrag
ord-e6c54f88312e4300a0c43d9c43586d53
Quelldatensatz
uspto-grants-2013_11
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US08586739B2

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